Brevianamide F

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Chemical Structure| 38136-70-8 同义名 : Cyclo(L-Pro-L-Trp);Cyclo-L-tryptophyl-L-proline;cyclo-(L-Trp-L-Pro)
CAS号 : 38136-70-8
货号 : A313042
分子式 : C16H17N3O2
纯度 : 99%+
分子量 : 283.325
MDL号 : MFCD29917326
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(176.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Brevianamide F, also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines[3]. Brevianamide F is the precursor of a variety of fungal prenylated alkaloids with biological activity, including fumitremorgins A, B and C and tryprostatin B[4]. Otherwise, brevianamide F analogues possess interesting breast cancer resistance protein inhibitory activity[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.53mL

0.71mL

0.35mL

17.65mL

3.53mL

1.76mL

35.30mL

7.06mL

3.53mL
参考文献

[1]Wauters I, Goossens H, et al. Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues. J Org Chem. 2015 Aug 21;80(16):8046-54.

[2]Yin S, Yu X, et al. Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides. Appl Microbiol Biotechnol. 2013 Feb;97(4):1649-60.

[3]Yin S, Yu X, Wang Q, Liu XQ, Li SM. Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides. Appl Microbiol Biotechnol. 2013 Feb;97(4):1649-60

[4]Maiya S, Grundmann A, Li SM, Turner G. The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase. Chembiochem. 2006 Jul;7(7):1062-9

[5]Wauters I, Goossens H, Delbeke E, Muylaert K, Roman BI, Van Hecke K, Van Speybroeck V, Stevens CV. Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues. J Org Chem. 2015 Aug 21;80(16):8046-54