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NPS-2143

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Chemical Structure| 284035-33-2 同义名 : SB-262470A;SB262470
CAS号 : 284035-33-2
货号 : A310585
分子式 : C24H25ClN2O2
纯度 : 98+%
分子量 : 408.921
MDL号 : MFCD04113010
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(39.13 mM)，配合低频超声，并调节pH至2，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • CaSR

    Ca(2+) receptor, IC50:43 nM
描述 NPS-2143 is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.23mL

2.45mL

1.22mL

24.45mL

4.89mL

2.45mL
参考文献

[1]Rybczynska A, Lehmann A, et al. Hypertensive effect of calcilytic NPS 2143 administration in rats. J Endocrinol. 2006 Oct;191(1):189-95.

[2]Nemeth EF, Delmar EG, et al. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone. J Pharmacol Exp Ther. 2001 Oct;299(1):323-31.