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Cinobufotalin

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Chemical Structure| 1108-68-5 同义名 : 华蟾素 ;NSC 90326
CAS号 : 1108-68-5
货号 : A309641
分子式 : C26H34O7
纯度 : 98+%
分子量 : 458.54
MDL号 : MFCD28396383
存储条件:

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(261.7 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Cinobufotalin is one of the bufadienolides prepared from toad venom with anticancer activity.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03236636 Hepatocellular Carcinoma (HCC) Phase 3 Not yet recruiting August 2019 -
NCT02860429 Gastrointestinal Neoplasms Phase 4 Unknown - China, Liaoning ... 展开 >> The First Affiliated Hospital of Dalian Medical University Not yet recruiting Dalian, Liaoning, China, 116000 Contact: Xiaonan Cui    +8618098876725    cxn23@sina.com    Liaoning Cancer Hospital Not yet recruiting Shenyang, Liaoning, China, 110000 Contact: Rui Zhang    +8613898872185    zzzrrr1234@sina.com 收起 <<
NCT03189992 Malignant Tumor of Small Intes... 展开 >>tine Metastatic to Liver 收起 << Phase 1 Recruiting December 2018 China ... 展开 >> Shang Hai TCM University Recruiting Shanghai, China Contact: shibing su    021-51323013    shibingsu07@163.com 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.18mL

0.44mL

0.22mL

10.90mL

2.18mL

1.09mL

21.81mL

4.36mL

2.18mL

参考文献

[1]Cheng L, Chen YZ, et al. Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells. Tumour Biol. 2015 Aug;36(8):5763-71.

[2]Kai S, Lu JH, et al. Pre-clinical evaluation of cinobufotalin as a potential anti-lung cancer agent. Biochem Biophys Res Commun. 2014 Sep 26;452(3):768-74.