Gemcitabine HCI
产品说明书
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同义名 : | 吉西他滨盐酸盐 ;LY 188011 hydrochloride;Gemcitabine(hydrochloride);Gemcitabine HCl;LY 188011(hydrochloride) |
| CAS号 : | 122111-03-9 | |
| 货号 : | A309564 | |
| 分子式 : | C9H12ClF2N3O4 | |
| 纯度 : | 97% | |
| 分子量 : | 299.659 | |
| MDL号 : | MFCD01735988 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 60 mg/mL(200.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(83.43 mM)，配合低频超声助溶 DMF: 2 mg/mL(6.67 mM)，配合低频超声助溶 |
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| 动物实验配方： |
PO 0.5% CMC-Na 32 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Gemcitabine hydrochloride is the hydrochloride form of Gemcitabine. Gemcitabine (dFdCTP, LY-188011, NSC 613327, (+)-2'-Deoxy-2',2'-difluorocytidine) is a deoxycytidine analogue that has a spectrum of activity against solid tumors[1]. Gemcitabine can inhibit DNA synthesis through a combination of two actions. The first, gemcitabine can inhibit ribonucleotide reductase (RR) and then cause the decrease of the deoxynucleotide pool sizes for DNA repair and synthesis[2][3]. The second, gemcitabine inhibit DNA synthesis through competition with dCTP and incorporation into DNA[4][4]. Gemcitabine can induce S-phase arrest and cell growth inhibition[6]. | ||
| 作用机制 | Gemcitabine, as nucleoside analogue, can inhibit DNA synthesis through inhibition of ribonucleotide reductase and incorporation into DNA.[2][3] | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活性说明 | 数据源 |
| CCRF-CEM | Growth Inhibition Assay | IC50=2.9 ± 1.8 nM | 22425885 | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=2.9 ± 1.8 nM | 22425885 | ||
| CCRF-CEM | Growth Inhibition Assay | 72 h | IC50=2.0 ± 0.6 nM | 21851843 | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.34mL 0.67mL 0.33mL |
16.69mL 3.34mL 1.67mL |
33.37mL 6.67mL 3.34mL |
| 参考文献 |
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