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GNF-PF-3777

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Chemical Structure| 77603-42-0 同义名 : 8-Nitrotryptanthrin
CAS号 : 77603-42-0
货号 : A309256
分子式 : C15H7N3O4
纯度 : 99%+
分子量 : 293.234
MDL号 : MFCD00618023
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 5 mg/mL(17.05 mM)，配合水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The typtanthrin derivative known as GNF-PF-3777, or 8-Nitrotryptanthrin, is a highly effective inhibitor of hIDO2, surpassing the commonly used L-1-MT in efficiency. The IC50 values indicate that all nine tryptanthrin derivatives inhibit hIDO2, with GNF-PF-3777 showing significantly stronger inhibition at 1.87 μM, compared to L-1-MT at 82.53 μM and D-1-MT at 262.75 μM. Additionally, GNF-PF-3777 has notable antitrypanosomal activity, with an EC50 of 0.82 μM[1]. In the microplate Alamar Blue assay, GNF-PF-3777's minimum inhibitory concentration (MIC) is 0.032 μg/mL, and it also has a LORA MIC of 2.4 μg/mL, whereas most analogues do not exhibit LORA activity[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.41mL

0.68mL

0.34mL

17.05mL

3.41mL

1.71mL

34.10mL

6.82mL

3.41mL
参考文献

[1]Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3.

[2]Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67.