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Sweroside

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Chemical Structure| 14215-86-2 同义名 : 1,9-trans-9,5-cis-Sweroside;(−)-Sweroside
CAS号 : 14215-86-2
货号 : A308538
分子式 : C16H22O9
纯度 : 97%
分子量 : 358.341
MDL号 : MFCD09954487
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(293.02 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(139.53 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Sweroside, a natural product isolated and purified from the herbs of Swertia bimaculata with strong hepatoprotective, anti-osteoporotic, insulin-mimicking, and wound-healing effects, can inhibit potent melanogenesis in melan-a cells at 300uM without cytotoxicity, also decreases tyrosinase, tyrosinase-related protein-1 (TRP-1) and TRP-2 protein production in melan a cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.95mL

2.79mL

1.40mL

27.91mL

5.58mL

2.79mL

参考文献

[1]Jeong YT, Jeong SC, et al. Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis. Chem Biol Interact. 2015 Aug 5;238:33-9.

[2]Ozturk N, Korkmaz S, et al. Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Planta Med. 2006 Mar;72(4):289-94.