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GSK-872

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Chemical Structure| 1346546-69-7 同义名 : GSK2399872A;GSK'872
CAS号 : 1346546-69-7
货号 : A306277
分子式 : C19H17N3O2S2
纯度 : 99%+
分子量 : 383.487
MDL号 : MFCD30481302
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(273.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GSK-872 is an inhibitor of RIPK3 that binds to the RIP3 kinase domain with an IC50 of 1.8 nM, and it inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 reduces RIPK3-mediated necroptotic cell death, subsequent cytoplasmic translocation, and expression of HMGB1, improving early brain injury-related cerebral edema and neurological deficits[1][2][3]. Within a concentration range of 0.01-3 μM, GSK-872 blocks TNF-induced necroptotic cell death in human HT-29 cells in a concentration-dependent manner over 24 hours[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.04mL

2.61mL

1.30mL

26.08mL

5.22mL

2.61mL
参考文献

[1]Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

[2]Arora D, et al. Deltamethrin induced RIPK3-mediated caspase-independent non-apoptotic cell death in rat primary hepatocytes. Biochem Biophys Res Commun. 2016 Oct 14;479(2):217-223.

[3]Chen T, et al. Inhibiting of RIPK3 attenuates early brain injury following subarachnoid hemorrhage: Possibly through alleviating necroptosis. Biomed Pharmacother. 2018;107:563-570.