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(E/Z)-BIX02188

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Chemical Structure| 1094614-84-2 同义名 : BIX 02188
CAS号 : 1094614-84-2
货号 : A302457
分子式 : C25H24N4O2
纯度 : 99%+
分子量 : 412.484
MDL号 : MFCD14584538
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

5% DMSO+40% PEG 300+water 5 mg/mL

生物活性
靶点

  • MEK5

    MEK5, IC50:4.3 nM
描述 BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.42mL

0.48mL

0.24mL

12.12mL

2.42mL

1.21mL

24.24mL

4.85mL

2.42mL
参考文献

[1]Tatake RJ, O'Neill MM, et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.

[2]Li L, Tatake RJ, Natarajan K, et al. Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63.