产品说明书

GS-6201

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Chemical Structure| 752222-83-6 同义名 : CVT-6883
CAS号 : 752222-83-6
货号 : A302129
分子式 : C21H21F3N6O2
纯度 : 99%+
分子量 : 446.426
MDL号 : MFCD11042420
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(235.2 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GS-6201, also known as CVT-6883, acts as a selective antagonist for the adenosine A2B receptor. It exhibits a strong affinity and specificity towards human adenosine A2B receptors, with an inhibition constant Ki value of 22 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.24mL

0.45mL

0.22mL

11.20mL

2.24mL

1.12mL

22.40mL

4.48mL

2.24mL
参考文献

[1]Elzein E, et al. Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. J Med Chem. 2008 Apr 10;51(7):2267-78.

[2]Toldo S, et al. GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. J Pharmacol Exp Ther. 2012 Dec;343(3):587-95.