产品说明书

WAY-600

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Chemical Structure| 1062159-35-6 同义名 : -
CAS号 : 1062159-35-6
货号 : A301338
分子式 : C28H30N8O
纯度 : 99%
分子量 : 494.591
MDL号 : MFCD22419019
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(50.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • mTOR

    mTOR, IC50:9 nM
描述 WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM and blocks mTORC1/P-S6K (T389) and mTORC2/P-AKT (S473) but not P-AKT (T308). It is selective for mTOR than PI3Kα (> 100-fold) and PI3Kγ (> 500-fold).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.11mL

2.02mL

1.01mL

20.22mL

4.04mL

2.02mL
参考文献

[1]Pan XD, Gu DH, et al. Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo. PLoS One. 2017 Mar 3;12(3):e0172555.

[2]Cheng F, Wang L, et al. Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent. Biochem Biophys Res Commun. 2016 Feb 5;470(2):324-330.