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Corilagin

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Chemical Structure| 23094-69-1 同义名 : -
CAS号 : 23094-69-1
货号 : A301056
分子式 : C27H22O18
纯度 : 99%+
分子量 : 634.453
MDL号 : MFCD00238565
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(165.5 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 5 mg/mL(7.88 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 Corilagin, a gallotannin, inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL[1]. Cori effectively protects against APAP(Acetaminophen)-induced ALF (acute liver failure) via the upregulation of the AMPK/GSK3β-Nrf2 signaling pathway[2]. Corilagin induced the apoptosis of gastric cancer cells mainly via activating caspase‑8, ‑9, ‑3 and poly ADP‑ribose polymerase proteins. Corilagin triggered autophagy in gastric cancer cells and the inhibition of autophagy improved the activity of corilagin on cell growth suppression. In addition, corilagin significantly increased intracellular reactive oxygen species production, which is important in inhibiting the growth of gastric cancer cells[3]. Corilagin can suppress schistosome egg-induced hepatic fibrosis via inhibition of M2 macrophage polarization in the IL-13Rα1 signaling pathway[4]. In addition, corilagin dose-dependently blocks SARS-CoV-2-RBD binding and abolishes the infectious property of RBD-pseudotyped lentivirus in hACE2 overexpressing HEK293 cells, which mimicked the entry of SARS-CoV-2 virus in human host cells[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.58mL

0.32mL

0.16mL

7.88mL

1.58mL

0.79mL

15.76mL

3.15mL

1.58mL
参考文献

[1]Li X, Deng Y, Zheng Z, Huang W, Chen L, Tong Q, Ming Y. Corilagin, a promising medicinal herbal agent. Biomed Pharmacother. 2018 Mar;99:43-50

[2]Lv H, Hong L, Tian Y, Yin C, Zhu C, Feng H. Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3β-Nrf2 signaling pathway. Cell Commun Signal. 2019 Jan 10;17(1):2

[3]Xu J, Zhang G, Tong Y, Yuan J, Li Y, Song G. Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro. Int J Mol Med. 2019 Feb;43(2):967-979

[4]Li YQ, Chen YF, Dang YP, Wang Y, Shang ZZ, Ma Q, Wang YJ, Zhang J, Luo L, Li QQ, Zhao L. Corilagin Counteracts IL-13Rα1 Signaling Pathway in Macrophages to Mitigate Schistosome Egg-Induced Hepatic Fibrosis. Front Cell Infect Microbiol. 2017 Oct 18;7:443

[5]Yang LJ, Chen RH, Hamdoun S, Coghi P, Ng JPL, Zhang DW, Guo X, Xia C, Law BYK, Wong VKW. Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding. Phytomedicine. 2021 Jul;87:153591