产品说明书

Remogliflozin etabonate

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Chemical Structure| 442201-24-3 同义名 : GSK189075
CAS号 : 442201-24-3
货号 : A297470
分子式 : C26H38N2O9
纯度 : 97%
分子量 : 522.588
MDL号 : MFCD17167013
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(200.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Remogliflozin etabonate (GSK189075) is an orally active, selective, and low-affinity sodium glucose cotransporter (SGLT2) inhibitor, with Ki values of 1.95 μM, 2.14 μM, 43.1 μM, and 8.57 μM for hSGLT2, rSGLT2, hSGLT1, and rSGLT1, respectively. It is a prodrug based on benzylpyrazole glucoside and is metabolized to its active form, Remogliflozin, within the body. This compound demonstrates antidiabetic efficacy in rodent models[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.91mL

0.38mL

0.19mL

9.57mL

1.91mL

0.96mL

19.14mL

3.83mL

1.91mL
参考文献

[1]Yoshikazu Fujimori, et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76.