产品说明书
Desonide
 |
同义名 : | Budesonide acetonide |
| CAS号 : | 638-94-8 | |
| 货号 : | A294822 | |
| 分子式 : | C24H32O6 | |
| 纯度 : | 98% | |
| 分子量 : | 416.507 | |
| MDL号 : | MFCD00866151 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(252.1 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
2% DMSO+49% PEG 300+dd water 10 mg/mL |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Desonide is a nonfluorinated corticosteroid anti-inflammatory agent used topically for dermatoses[3]. Desonide topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions (eg, atopic dermatitis). Desonide showed depigmenting properties in women with axillary hyperpigmentation. It induced significant colorimetric improvement compared with placebo.[4]. The in vitro skin permeation showed that desonide reached the site of action of the topical corticosteroids, from both formulations (57.8 and 51.7 µg/cm2); however, the desonide amount retained in the dermis was lower with D-GC (gel-cream developed)[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01935310 | Photoaging | Not Applicable | Completed | - | Colombia ... 展开 >> Centro de servicios CES Sabaneta Medellín, Antioquia, Colombia, 050021 收起 << |
| NCT03758365 | Vasoconstriction | Phase 1 | Recruiting | January 15, 2019 | France ... 展开 >> CPCAD Recruiting Nice, France, 06200 Contact: Catherine Queille-Roussel, MD 收起 << |
| NCT02732314 | Dermatitis, Atopic ... 展开 >> Eczema 收起 << | Phase 4 | Completed | - | United States, North Carolina ... 展开 >> Wake Research Associates, LLC Raleigh, North Carolina, United States, 27612 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.40mL 0.48mL 0.24mL |
12.00mL 2.40mL 1.20mL |
24.01mL 4.80mL 2.40mL |
| 参考文献 |
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