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5,7-Dichlorokynurenic acid

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Chemical Structure| 131123-76-7 同义名 : 5,7-DCKA;DCKA;DKC
CAS号 : 131123-76-7
货号 : A289769
分子式 : C10H5Cl2NO3
纯度 : 95%
分子量 : 258.058
MDL号 : MFCD00083173
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(96.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 5,7-Dichlorokynurenic acid acts as a selective and competitive blocker for the glycine binding site on the NMDA receptor, with a Kb value of 65 nM. As a kynurenic acid derivative, 5,7-Dichlorokynurenic acid has been shown to mitigate neuron damage induced by NMDA in rat cortical cell cultures[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.88mL

0.78mL

0.39mL

19.38mL

3.88mL

1.94mL

38.75mL

7.75mL

3.88mL
参考文献

[1]D McNamara, et al.  5,7-Dichlorokynurenic acid, a potent and selective competitive antagonist of the glycine site on NMDA receptors. Neurosci Lett. 1990 Nov 27;120(1):17-20.