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D-α-Hydroxyglutaric acid disodium

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Chemical Structure| 103404-90-6 同义名 : 2-羟基-D-谷氨酸 二钠盐 ;Disodium (R)-2-hydroxyglutarate;D-2-HG;MDK4906;D-2-Hydroxyglutaric Acid;D-α-Hydroxyglutaric Acid (sodium salt)
CAS号 : 103404-90-6
货号 : A289466
分子式 : C5H6Na2O5
纯度 : 95%
分子量 : 192.078
MDL号 : MFCD00069573
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 75 mg/mL(390.47 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 D-alpha-Hydroxyglutaric acid disodium is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-alpha-Hydroxyglutaric acid ((R)-2-hydroxyglutarate) accumulates in human cancers carrying neomorphic mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. Tumor-derived IDH1 and IDH2 mutations reduce alpha-KG and accumulate an α-KG antagonist, 2-HG, leading to genome-wide histone and DNA methylation alterations. D-α-Hydroxyglutaric acid is a weak inhibitor of TET hydroxylases. In the presence of 0.1 mM of alpha-KG, addition of 10 mM D-alpha-Hydroxyglutaric acid results in a partial (33%) inhibition of TET2 and addition of 50 mM D-α-Hydroxyglutaric acid results in more inhibition (83%) of TET2. D-alpha-Hydroxyglutaric acid exhibits a less pronounced inhibitory effect toward TET1[3]. D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism. D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.21mL

1.04mL

0.52mL

26.03mL

5.21mL

2.60mL

52.06mL

10.41mL

5.21mL
参考文献

[1]Fu X, Chin RM, et al. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell Metab. 2015 Sep 1;22(3):508-15.

[2]Xu W, Yang H, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

[3]Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30

[4]Latini A, Scussiato K, Rosa RB, Llesuy S, Belló-Klein A, Dutra-Filho CS, Wajner M. D-2-hydroxyglutaric acid induces oxidative stress in cerebral cortex of young rats. Eur J Neurosci. 2003 May;17(10):2017-22