产品说明书
Aminoguanidine HCl
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同义名 : | 肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐） ;Pimagedine hydrochloride;GER-11;Guanylhydrazine hydrochloride;GER11. aminoguanidine. Pimagedine hydrochloride;MDL201228;YM-585;Pimagedine, MDL-201228;Aminoguanidine (hydrochloride);Monoaminoguanidine;Imino semicarbazide;Hydrazinecarboximidamide;Guanyl hydrazine;Pimagedine;Aminoguanidinium chloride;Aminoguanidine hydrochloride |
| CAS号 : | 1937-19-5 | |
| 货号 : | A287191 | |
| 分子式 : | CH7ClN4 | |
| 纯度 : | 98% | |
| 分子量 : | 110.546 | |
| MDL号 : | MFCD00039074 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(949.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(904.6 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy. Combination of sub-threshold dose of meloxicam (1 mg/kg) with increasing doses of aminoguanidine hydrochloride (30, 100 and 300 mg/kg) resulted in synergistic anti-inflammatory effect. Combined therapy with sub-threshold dose of aminoguanidine hydrochloride (30 mg/kg) with increasing doses of meloxicam (1, 3, 10 and 30 mg/kg) also resulted in synergistic anti-inflammatory effect[3]. Combination of a subthreshold dose of rofecoxib (1 mg/kg) with increasing doses of aminoguanidine hydrochloride (30, 100 and 300 mg/kg) resulted in potentiated antinociception. Combined therapy with a subthreshold dose of aminoguanidine hydrochloride (30 mg/kg) with increasing doses of rofecoxib (1, 3, 10 and 30 mg/kg) also resulted in significant antinociception. Thus, rofecoxib and aminoguanidine hydrochloride act synergistically in their antinociceptive action in mice[4]. The fever index calculated for rats pretreated with v-LNIO or with aminoguanidine and injected with LPS (lipopolisaccharide) was reduced by 43% and 72%, respectively, compared to that calculated for water-pretreated and LPS-injected rats. Whereas vL-NIO (Vinyl-L-NIO (N(5) - (1-Imino-3-butenyl) - ornithine) partly attenuated both phases of febrile rise in T(b), administration of aminoguanidine into the brain completely prevented fever induced by LPS[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
9.05mL 1.81mL 0.90mL |
45.23mL 9.05mL 4.52mL |
90.46mL 18.09mL 9.05mL |
| 参考文献 |
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