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β-Carotene

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Chemical Structure| 7235-40-7 同义名 : β-胡萝卜素 ;Provitamin A;beta-Carotene;Solatene;Provatene;NSC 62794;Lucarotin;KPMK;Food Orange 5
CAS号 : 7235-40-7
货号 : A286364
分子式 : C40H56
纯度 : 98%
分子量 : 536.873
MDL号 : MFCD00001556
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1 mg/mL(1.86 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

THF: 10 mg/mL(18.63 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 β-Carotene (beta-carotene), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. Hmox1 (heme oxygenase 1) mRNA, but not Cox2 (cyclooxygenase-2) and Nos2 (nitric oxide synthase 2) mRNA, was up-regulated by 100 μM β-carotene and lycopene, and by 0.125% TBB (Tri-n-butyl borane). LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 μM β-carotene and lycopene, and by 0.5-1% TBB. Both β-carotene and lycopene had weak antioxidant activity, but β-carotene showed pro-oxidant activity at higher concentrations[3]. beta-carotene significantly increased PPAR-gamma mRNA and protein levels in time-dependent manner. In addition, beta-carotene increased the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) expression and decreased the prostanoid synthesis rate-limiting enzyme cyclooxygenase-2 expression. Further, reactive oxygen species (ROS) production was induced by beta-carotene, resulting in mitochondrial dysfunction and cytochrome C release[4]. Furthermore, the combination of beta-carotene with ethanol results in hepatotoxicity. Moreover, in smokers who also consume alcohol, beta-carotene supplementation promotes pulmonary cancer and, possibly, cardiovascular complications. Thus ethanol, while promoting a deficiency of vitamin A also enhances its toxicity as well as that of beta-carotene[5]. Supplementation with β-carotene increases the risk of lung cancer in smokers regardless of the tar or nicotine content of cigarettes smoked[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01290250 Overweight Ob... 展开 >>esity 收起 << Not Applicable Completed - Spain ... 展开 >> Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology, Center for Biomedical Research, University of Granada, Spain, 18071 收起 <<
NCT01488656 Inflammation Not Applicable Completed - -
NCT01951313 Will Consuming Eggs With a Mix... 展开 >>ed Vegetable Salad Increase Carotenoid Absorption 收起 << Not Applicable Completed - United States, Indiana ... 展开 >> Purdue University West Lafayette, Indiana, United States, 47907 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.63mL

3.73mL

1.86mL
参考文献

[1]Tanumihardjo SA. Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res. 2002 Jan;72(1):40-5.

[2]Leo MA, Lieber CS. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr. 1999 Jun;69(6):1071-85.

[3]Kawata A, Murakami Y, Suzuki S, Fujisawa S. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr;32(2):255-264

[4]Cui Y, Lu Z, Bai L, Shi Z, Zhao WE, Zhao B. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43(17):2590-601

[5]Leo MA, Lieber CS. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr. 1999 Jun;69(6):1071-85

[6]Middha P, Weinstein SJ, Männistö S, Albanes D, Mondul AM. β-Carotene Supplementation and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: The Role of Tar and Nicotine. Nicotine Tob Res. 2019 Jul 17;21(8):1045-1050