产品说明书

Trazodone

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Chemical Structure| 19794-93-5 同义名 : AF-1161 free base;AF-1161
CAS号 : 19794-93-5
货号 : A285442
分子式 : C19H22ClN5O
纯度 : 98+%
分子量 : 371.864
MDL号 : MFCD00242886
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(282.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • 5-HT
描述 Trazodone is an antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02559167 Substance Use Disorder ... 展开 >> Cocaine Dependence Withdrawal From Addictive Substance; Detoxification 收起 << Phase 2 Recruiting December 2019 Canada, Quebec ... 展开 >> Centre de recherche du Centre Hospitalier de l'Université de Montréal Recruiting Montreal, Quebec, Canada, H2X 0A9 Contact: Diego Arizala, M.A    514 890-8000 ext 30950    diego.arizala.chum@ssss.gouv.qc.ca    Contact: Amel Zertal, MSc    514 890-8000 ext 36153    amel.zertal.chum@ssss.gouv.qc.ca 收起 <<
NCT01347541 Posttraumatic Stress Disorder Phase 1 Unknown April 2013 United States, Washington ... 展开 >> Harborview Medical Center Seattle, Washington, United States, 98104 收起 <<
NCT00270959 Post-Traumatic Stress Disorder Phase 1 Unknown December 2015 United States, Washington ... 展开 >> Harborview Medical Center Seattle, Washington, United States, 98104 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.45mL

2.69mL

1.34mL

26.89mL

5.38mL

2.69mL
参考文献

[1]Camargos EF, Louzada LL, et al. Trazodone improves sleep parameters in Alzheimer disease patients: a randomized, double-blind, and placebo-controlled study. Am J Geriatr Psychiatry. 2014 Dec;22(12):1565-74.

[2]Fagiolini A, Comandini A, et al. Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs. 2012 Dec;26(12):1033-49. doi: 10.1007/s40263-012-0010-5.