产品说明书

GNF351

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Chemical Structure| 1227634-69-6 同义名 : -
CAS号 : 1227634-69-6
货号 : A282299
分子式 : C24H25N7
纯度 : 99%+
分子量 : 411.502
MDL号 : MFCD23726597
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(291.61 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 GNF351 is an AHR antagonist with an IC50 value of 62 nM. GNF351 has minimal toxicity to mouse or human keratinocytes[1].Treatment of cells with GNF351 at a concentration of 500 nM for 48 hours significantly reduced the percentage of Ki67-positive cells and the number of cells in a proliferative monolayer culture assay of human keratinocytes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.15mL

2.43mL

1.22mL

24.30mL

4.86mL

2.43mL
参考文献

[1]van den Bogaard EH, et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.