产品说明书

Lansoprazole

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Chemical Structure| 103577-45-3 同义名 : AG-1749;A-65006;Lansoprazole, AG-1749, Prevacid, Zoton, Agopton, Bamalite, Opiren
CAS号 : 103577-45-3
货号 : A281446
分子式 : C16H14F3N3O2S
纯度 : 98%
分子量 : 369.361
MDL号 : MFCD00866873
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • Proton Pump
描述 Lansoprazole (AG 1749) is an oral proton pump inhibitor that effectively suppresses gastric acid secretion. Additionally, Lansoprazole (AG 1749) demonstrates potent inhibition of neutral sphingomyelinase (N-SMase), making it a brain-penetrant exosome inhibitor[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.07mL

5.41mL

2.71mL
参考文献

[1]Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5.

[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

[3]Rupinder K Sodhi, et al. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS One. 2013 Jul 31;8(7):e70487.

[4]Jun Matsukawa, et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 2011 May 1;81(9):1145-51.

[5]Erdinc Naseri, et al. Proton pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries. Eur J Pharmacol. 2006 Feb 15;531(1-3):226-31.