产品说明书
Darovasertib
 |
同义名 : | Lxs196;IDE196 |
| CAS号 : | 1874276-76-2 | |
| 货号 : | A279706 | |
| 分子式 : | C22H23F3N8O | |
| 纯度 : | 99%+ | |
| 分子量 : | 472.466 | |
| MDL号 : | MFCD31544328 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(52.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Darovasertib, also known as LXS196, is an effective, selective, orally active PKC inhibitor, with IC50 values of 1.9 nM for PKCα, 0.4 nM for PKCθ, and 3.1 μM for GSK3β. Darovasertib holds potential for research in uveal melanoma[1][2]. Upon oral administration, Darovasertib binds to and inhibits PKC, thereby preventing the activation of PKC-mediated signaling pathways. This may result in cell cycle arrest and the induction of apoptosis in sensitive tumor cells[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.12mL 0.42mL 0.21mL |
10.58mL 2.12mL 1.06mL |
21.17mL 4.23mL 2.12mL |
| 参考文献 |
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