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Schisandrin A

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Chemical Structure| 61281-38-7 同义名 : Schizandrin-A;Wuweizisu-A;Deoxyschisandrin;Deoxyschizandrin
CAS号 : 61281-38-7
货号 : A279617
分子式 : C24H32O6
纯度 : 98%
分子量 : 416.507
MDL号 : MFCD09026934
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(120.05 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Schisandrin A (SchA) is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 µM[3]. SchA produced concentration-dependent inhibition of MDZ (midazolam) metabolite formation in rat liver microsomes[4]. Sch A reduced LPS-induced mammary injury and the production of pro-inflammatory mediators. Sch A also decreased the levels of pro-inflammatory mediators and activated Nrf2 signaling pathway in mouse mammary epithelial cells (mMECs)[5]. Schisandrin A could suppress the IL-1β-induced production of NO and PGE2 in rat chondrocytes. In vivo, Schisandrin A prevented cartilage damage in rat OA (Osteoarthritis) model[6]. Sch A significantly ameliorated behavioural abnormalities and increased the number of nigral dopaminergic neurons detected by tyrosine hydroxylase immunohistochemistry. Pre-treatment with Sch A significantly decreased the levels of the inflammatory mediators IL-6, IL-1β, and TNF-α and markedly improved antioxidant defences by inhibiting the activity of MDA and increasing that of SOD. Furthermore, Sch A activated expression of the autophagy-related proteins LC3-II, beclin1, parkin, and PINK1 and increased mTOR expression[7]. Sch A appeared to protect against DON(deoxynivalenol)-induced cytotoxicity in HT-29 cells, and significantly lessened the DON-stimulated intracellular ROS and NO species production[8]. Schisandrin A has a protective effect against LPS-induced inflammatory and oxidative responses in RAW 264.7 cells by inhibiting the NF-κB, MAPK and PI3K/Akt pathways[9].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.01mL

4.80mL

2.40mL
参考文献

[1]Wang CP, Li GC, et al. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons. J Physiol Biochem. 2014 Sep;70(3):735-47.

[2]Liang XX, Liu GT, et al. Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A. J Asian Nat Prod Res. 2010 Jul;12(7):549-56.

[3]Li WL, Xin HW, Su MW, Xiong L. Inhibitory effects of schisandrin A and schisandrin B on CYP3A activity. Methods Find Exp Clin Pharmacol. 2010 Apr;32(3):163-9

[4]Li WL, Xin HW, Su MW. Inhibitory effects of continuous ingestion of Schisandrin A on CYP3A in the rat. Basic Clin Pharmacol Toxicol. 2012 Feb;110(2):187-92

[5]Xu D, Liu J, Ma H, Guo W, Wang J, Kan X, Li Y, Gong Q, Cao Y, Cheng J, Fu S. Schisandrin A protects against lipopolysaccharide-induced mastitis through activating Nrf2 signaling pathway and inducing autophagy. Int Immunopharmacol. 2020 Jan;78:105983

[6]Tu C, Huang X, Xiao Y, Song M, Ma Y, Yan J, You H, Wu H. Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes. Front Pharmacol. 2019 Jan 29;10:41

[7]Zhi Y, Jin Y, Pan L, Zhang A, Liu F. Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy. Arch Pharm Res. 2019 Nov;42(11):1012-1020

[8]Wan MLY, Turner PC, Co VA, Wang MF, Amiri KMA, El-Nezami H. Schisandrin A protects intestinal epithelial cells from deoxynivalenol-induced cytotoxicity, oxidative damage and inflammation. Sci Rep. 2019 Dec 16;9(1):19173

[9]Kwon DH, Cha HJ, Choi EO, Leem SH, Kim GY, Moon SK, Chang YC, Yun SJ, Hwang HJ, Kim BW, Kim WJ, Choi YH. Schisandrin A suppresses lipopolysaccharide-induced inflammation and oxidative stress in RAW 264.7 macrophages by suppressing the NF-κB, MAPKs and PI3K/Akt pathways and activating Nrf2/HO-1 signaling. Int J Mol Med. 2018 Jan;41(1):264-274