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Mogroside III-E

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Chemical Structure| 88901-37-5 同义名 : 罗汉果甜苷 III-E;罗汉果甜甙 III-E;罗汉果甙 III-E;罗汉果皂苷ⅢE
CAS号 : 88901-37-5
货号 : A275138
分子式 : C48H82O19
纯度 : 98%
分子量 : 963.153
MDL号 : MFCD28124365
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(109.02 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mogroside IIIE (MGIIIE), a cucurbitane-type compound, a crucial inflammatory factor, from lipopolysaccharide (LPS)-treated RAW264.7 cells compared with other mogrosides. In the pulmonary fibrosis mouse model induced by bleomycin, MGIIIE treatment attenuated pulmonary fibrosis, indicated as a reduction in myeloperoxidase activity, collagen deposition, and pathologic score[3]. MG IIIE elevated the cell viability of HG-induced (high glucose) MPC-5 cells, reduced the concentrations of inflammatory cytokines and decreased the levels of oxidative stress-related markers[4]. Mogroside IIIE greatly improved glucose metabolism, insulin tolerance, and reproductive outcome of the GDM mice. Moreover, Mogroside IIIE treatment significantly decreased inflammatory factors expression and relieved GDM symptoms through enhanced AMPK activation, inhibited HDAC4 expression, and reduced production of G6Pase. The alleviation of GDM by Mogroside IIIE was mediated by elevated AMPK activation, which in turn inhibited HDAC4 phosphorylation, and eventually down-regulated G6Pase expression and activity[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.04mL

0.21mL

0.10mL

5.19mL

1.04mL

0.52mL

10.38mL

2.08mL

1.04mL
参考文献

[1]Tao L, Cao F, et al. Mogroside IIIE Attenuates LPS-Induced Acute Lung Injury in Mice Partly Through Regulation of the TLR4/MAPK/NF-κB Axis via AMPK Activation. Phytother Res. 2017 May 17.

[2]Tao L, Yang J, et al. Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways. J Pharmacol Exp Ther. 2017 May;361(2):268-279.

[3]Tao L, Yang J, Cao F, Xie H, Zhang M, Gong Y, Zhang C. Mogroside IIIE, a Novel Anti-Fibrotic Compound, Reduces Pulmonary Fibrosis through Toll-Like Receptor 4 Pathways. J Pharmacol Exp Ther. 2017 May;361(2):268-279

[4]Xue W, Mao J, Chen Q, Ling W, Sun Y. Mogroside IIIE Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Podocytes by the Activation of AMPK/SIRT1 Signaling Pathway. Diabetes Metab Syndr Obes. 2020 Oct 20;13:3821-3830