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Sivelestat Sodium Tetrahydrate

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Chemical Structure| 201677-61-4 同义名 : ONO5046 sodium tetrahydrate;EI546 sodium tetrahydrate;ONO-5046;LY544349;Sivelestat (sodium salt hydrate);LY544349 sodium;EI546 sodium;Sodium sivelestat;ONO5046-Na;Sivelestat sodium;LY544349 sodium tetrahydrate
CAS号 : 201677-61-4
货号 : A274870
分子式 : C20H29N2NaO11S
纯度 : 99%+
分子量 : 528.51
MDL号 : MFCD01937969
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(473.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM.This compound is under investigation for its potential use in the treatment of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) or disseminated intravascular coagulation (DIC), particularly in the context of COVID-19[1].[2].[3].[4].
作用机制 Sivelestat sodium tetrahydrate is an intravenously active NE inhibitor that competitively binds to the target substrate of NE.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.89mL

0.38mL

0.19mL

9.46mL

1.89mL

0.95mL

18.92mL

3.78mL

1.89mL
参考文献

[1]Kawabata K, et al. ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.

[2]Yuichiro Toda, et al. A neutrophil elastase inhibitor, sivelestat, ameliorates lung injury after hemorrhagic shock in rats. Int J Mol Med. 2007 Feb;19(2):237-43.

[3]Tomoharu Kono, et al. Neutrophil elastase inhibitor, sivelestat sodium hydrate prevents ischemia-reperfusion injury in the rat bladder. Mol Cell Biochem. 2008 Apr;311(1-2):87-92.

[4]Adeleh Sahebnasagh, et al. Neutrophil elastase inhibitor (sivelestat) may be a promising therapeutic option for management of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19. J Clin Pharm Ther. 2