产品说明书

SBAP

Print
Chemical Structure| 57159-62-3 同义名 : N-Succinimidyl 3-(Bromoacetamido)propionate;3-(2-Bromoacetamido)propanoic acid NHS ester;WUN 59623
CAS号 : 57159-62-3
货号 : A273905
分子式 : C9H11BrN2O5
纯度 : 95%
分子量 : 307.098
MDL号 : MFCD01863457
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 N-Succinimidyl 3-(Bromoacetamido)propionate is a PEG-based PROTAC linker used in the synthesis of PROTACs[1]. N-Succinimidyl 3-(Bromoacetamido)propionate serves as a cleavable ADC linker in the synthesis of antibody-drug conjugates (ADCs)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.26mL

0.65mL

0.33mL

16.28mL

3.26mL

1.63mL

32.56mL

6.51mL

3.26mL
参考文献

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

[2]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.