Ayanin

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Chemical Structure| 572-32-7 同义名 : -
CAS号 : 572-32-7
货号 : A273394
分子式 : C18H16O7
纯度 : 98%+
分子量 : 344.315
MDL号 : MFCD03844820
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(726.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ayanin, a natural product isolated and purified from the rhizomes of Curcuma aromatica, with vasorelaxant activity and may have the potential for use in treating allergic asthma. Its IC(50) value 2.2mM for inhibiting interleukin (IL)-4 production from purified basophils.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.52mL

2.90mL

1.45mL

29.04mL

5.81mL

2.90mL
参考文献

[1]Marrero MT, Estevez S, et al. Ayanin diacetate-induced cell death is amplified by TRAIL in human leukemia cells. Biochem Biophys Res Commun. 2012 Nov 9;428(1):116-20.

[2]Lee FP, Shih CM, et al. Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2010 Jun 10;635(1-3):198-203.