Taxifolin

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Chemical Structure| 480-18-2 同义名 : 二氢槲皮素 ;(+)-Dihydroquercetin;Dihydroquercetin;Catechin hydrate;Lavitol;Lariksin;Taxifoliol;(+)-Taxifolin
CAS号 : 480-18-2
货号 : A271339
分子式 : C15H12O7
纯度 : 98%
分子量 : 304.252
MDL号 : MFCD15146487
存储条件:

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(345.11 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Taxifolin has an important anti tyrosinase activity. Taxifolin effectively inhibited collagenase, IC50 was 193.3 μ M[3]. The apparent permeability of taxifolin across Caco-2 cell monolayersa (widely used in vitro model of the human small intestinal mucosa) was shown to be less than 1 × 10−6 cm/s, and the absolute bioavailability of taxifolin was reported as 0.17% in rats. Moreover, the urinary excretion of taxifolin was found to be only 0.24% of the dosage[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.29mL

0.66mL

0.33mL

16.43mL

3.29mL

1.64mL

32.87mL

6.57mL

3.29mL

参考文献

[1]Yang P, Xu F, et al.Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.

[2]Lee SB, Cha KH, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9.

[3]Angelis A, Hubert J, Aligiannis N, Michalea R, Abedini A, Nuzillard JM, Gangloff SC, Skaltsounis AL, Renault JH. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586. doi: 10.3390/molecules21111586. PMID: 27879645; PMCID: PMC6272914.

[4]Yang P, Xu F, Li HF, Wang Y, Li FC, Shang MY, Liu GX, Wang X, Cai SQ. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9):1209. doi: 10.3390/molecules21091209. PMID: 27649117; PMCID: PMC6273498.