产品说明书
ML171
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同义名 : | 2-Acetylphenothiazine;2-APT;Ethanone, 1-(10H-phenothiazin-2-yl)-;1-(10H-Phenothiazin-2-yl)ethanone;6631-94-3;NSC 169669;NSC 57951 |
| CAS号 : | 6631-94-3 | |
| 货号 : | A269257 | |
| 分子式 : | C14H11NOS | |
| 纯度 : | 98% | |
| 分子量 : | 241.308 | |
| MDL号 : | MFCD00005017 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 65 mg/mL(269.37 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nox1-dependent ROS production is crucial for cell signaling, growth, angiogenesis, motility, and blood pressure regulation. ML171 effectively inhibits ROS generation in HT29 cells (IC50=0.129 µM), and only an increased over-expression of Nox1 can counteract the suppression of ROS production by ML171 in a HEK293 cell system outfitted with all elements necessary for Nox1-dependent ROS production. ML171 significantly reduces ROS output, as indicated by carboxy-H2-DCFDA staining, with efficacy comparable to DPI, the positive control. In the HEK293-Nox1 reconstituted cell system, ML171 demonstrates enhanced effectiveness in inhibiting Nox1-dependent ROS generation compared to the original compound[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.14mL 0.83mL 0.41mL |
20.72mL 4.14mL 2.07mL |
41.44mL 8.29mL 4.14mL |
| 参考文献 |
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