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Vanillyl alcohol

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Chemical Structure| 498-00-0 同义名 : 4-(羟甲基)-2-甲氧基苯酚 ;p-(Hydroxymethyl)guaiacol;Vanillin alcohol;4-Hydroxy-3-methoxybenzenemethanol;3-Methoxy-4-hydroxybenzyl alcohol;Vanillic alcohol;4-Hydroxy-3-methoxybenzyl alcohol
CAS号 : 498-00-0
货号 : A266033
分子式 : C8H10O3
纯度 : 95%
分子量 : 154.163
MDL号 : MFCD00004659
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(681.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Vanillyl alcohol is a phenolic alcohol and is used as a flavoring agent in foods and beverages. Vanillyl alcohol displayed a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. Vanillyl alcohol was also shown to contain anti-inflammatory activity using acetic acid-induced permeability and carrageenan-induced air pouch models in mice. Anti-nociceptive activity of vanillyl alcohol was also assessed using acetic acid-induced writhing test in mice[3]. Vanillyl alcohol attenuated the elevation of reactive oxygen species (ROS) levels, decreased in the Bax/Bcl-2 ratio and poly (ADP-ribose) polymerase proteolysis. Thus vanillyl alcohol protected dopaminergic MN9D cells against MPP+-(1-methyl-4-phenylpyridinium) induced apoptosis by relieving oxidative stress and modulating the apoptotic process[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.49mL

1.30mL

0.65mL

32.43mL

6.49mL

3.24mL

64.87mL

12.97mL

6.49mL
参考文献

[1]Dimitrijevic A, Velickovic D, et al. Specificity of maltase to maltose in three different directions of reaction: hydrolytic, vanillyl alcohol glucoside and vanillyl alcohol isomaltoside synthesis. Biotechnol Prog. 2012 Nov-Dec;28(6):1450-6.

[2]Kim IS, Choi DK, Jung HJ. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules. 2011 Jun 24;16(7):5349-61.

[3]Jung HJ, Song YS, Lim CJ, Park EH. Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillyl alcohol. Arch Pharm Res. 2008 Oct;31(10):1275-9

[4]Kim IS, Choi DK, Jung HJ. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules. 2011 Jun 24;16(7):5349-61