产品说明书

Farrerol

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Chemical Structure| 24211-30-1 同义名 : -
CAS号 : 24211-30-1
货号 : A264602
分子式 : C17H16O5
纯度 : 98%
分子量 : 300.306
MDL号 : MFCD28347824
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(399.59 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Farrerol is a natural product isolated and purified from the leaves of Rhododendron dauricum L. with antioxidative activity. It inactivates KEAP-1 or activates the Akt, p38 and ERK to facilitate the release of Nrf2 from Keap1 and subsequent reduces the intracellular production of reactive oxygen species via the induction of HO-1 expression. Farrerol has protective effects against H2O2-induced apoptosis in EA.hy926 cells, and suggests that farrerol is a potential candidate for the intervention of endothelial-injury-associated cardiovascular diseases.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.33mL

0.67mL

0.33mL

16.65mL

3.33mL

1.66mL

33.30mL

6.66mL

3.33mL

参考文献

[1]Ci X, Lv H, et al. The antioxidative potential of farrerol occurs via the activation of Nrf2 mediated HO-1 signaling in RAW 264.7 cells. Chem Biol Interact. 2015 Sep 5;239:192-9.

[2]Qiu J, Xiang H, et al. Subinhibitory concentrations of farrerol reduce α-toxin expression in Staphylococcus aureus. FEMS Microbiol Lett. 2011 Feb;315(2):129-33.