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Domperidone

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Chemical Structure| 57808-66-9 同义名 : R33812;KW 5338;Domperidona;Motilium;NSC 299589
CAS号 : 57808-66-9
货号 : A264038
分子式 : C22H24ClN5O2
纯度 : 99+%
分子量 : 425.911
MDL号 : MFCD00069256
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(117.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • D2 receptor
描述 Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00308334 Low Breast Milk Supply Phase 2 Phase 3 Completed - Canada, Nova Scotia ... 展开 >> IWK Health Centre Halifax, Nova Scotia, Canada, B3K 6R8 收起 <<
NCT03610217 Scleroderma, Systemic ... 展开 >> Sclerosis, Systemic 收起 << Not Applicable Not yet recruiting October 2021 Canada, Ontario ... 展开 >> Saint Joseph's Health Care London Not yet recruiting London, Ontario, Canada, n6a 4v2 Contact: Janet E Pope, MD, MPH, FRCPSC    15196466332    Janet.Pope@sjhc.london.on.ca    Contact: Andreu Fernandez-Codina    151964661023    doccodina@gmail.com 收起 <<
NCT02779920 Gastroparesis Not Applicable Completed - France ... 展开 >> CHU de LIMOGES Limoges, France, 87042 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.23mL

11.74mL

2.35mL

1.17mL

23.48mL

4.70mL

2.35mL
参考文献

[1]Sudakov SK, Bashkatova VG. Effect of peripheral D₂ dopamine receptor antagonist domperidone on metabolism, feeding behavior, and locomotor activity of rats. Bull Exp Biol Med. 2013 Oct;155(6):705-7.

[2]Miles ED, Xue Y, et al. Ergopeptines bromocriptine and ergovaline and the dopamine type-2 receptor inhibitor domperidone inhibit bovine equilibrative nucleoside transporter 1-like activity. J Agric Food Chem. 2011 Sep 14;59(17):9691-9.