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Thymoquinone

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Chemical Structure| 490-91-5 同义名 : NSC 2228
CAS号 : 490-91-5
货号 : A263475
分子式 : C10H12O2
纯度 : 99%
分子量 : 164.201
MDL号 : MFCD00001602
存储条件:

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(639.46 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa seeds and has pharmacological actions including anti-oxidant, anti-inflammatory, immunomodulatory, anti-histaminic, anti-microbial and anti-tumor effects.An LD50 of 10 mg/kg for TQ when injected intraperitoneally in rats. The maximum tolerated dose for intraperitoneal injection was 22.5 mg/kg in male and 15 mg/kg in female rats, whereas for oral ingestion it was 250 mg/kg, in both male and female rats. in vitro, TQ also acted as inhibitor of COX-1 and -2, also inhibiting p38 in murine macrophages[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03208790 Premalignant Lesion Phase 2 Not yet recruiting December 2019 -
NCT03776448 Diabetes Mellitus Not Applicable Not yet recruiting February 2019 Saudi Arabia ... 展开 >> Sulaiman AlRajhi Colleges Not yet recruiting Al Bukairiyah, Qassim, Saudi Arabia, 51941, PO Box 777 Contact: Nazmus Saquib, Phd    966 533445899    a.saquib@sr.edu.sa    Principal Investigator: Nazmus Saquib, Phd          Sub-Investigator: Ahmed Abduljalil 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.09mL

1.22mL

0.61mL

30.45mL

6.09mL

3.05mL

60.90mL

12.18mL

6.09mL

参考文献

[1]Ahmad I, Akhter S, et al. Supercritical anti-solvent technique assisted synthesis of thymoquinone liposomes for radioprotection: Formulation optimization, in-vitro and in-vivo studies. Int J Pharm. 2017 May 15;523(1):398-409.

[2]Elsherbiny NM, Maysarah NM, et al. Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis. Life Sci. 2017 May 8. pii: S0024-3205(17)30224-2.

[3]Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S. Thymoquinone and its therapeutic potentials. Pharmacol Res. 2015 May-Jun;95-96:138-58. doi: 10.1016/j.phrs.2015.03.011. Epub 2015 Mar 28. PMID: 25829334.