产品说明书
Tricarballylic acid
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同义名 : | 1,2,3-丙烷三甲酸;丙三酸;丙烷-1,2,3-三羧酸 |
| CAS号 : | 99-14-9 | |
| 货号 : | A263335 | |
| 分子式 : | C6H8O6 | |
| 纯度 : | 97% | |
| 分子量 : | 176.124 | |
| MDL号 : | MFCD00002723 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(1419.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Tricarballylic acid, a conjugate acid of a tricarballylate, is a competitive inhibitor of the enzyme aconitate hydratase (aconitase; EC 4.2.1.3) with a Ki value of 0.52 mM[2]. Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-α, linking citrate's augmentation effect with its metabolism by ATP-citrate lyase. In the presence of citrate, increased histone acetylation was observed in the TNF-α and IL-8 promoter regions of THP-1 cells[3]. Tricarballylic acid (a substrate analogue of D-isocitric acid) gives competitive inhibition versus D-isocitrate at all NADP levels and mixed inhibition versus NADP, at sub-saturating levels of D-isocitrate[4]. Tricarballylic acid is a non-metabolizable rumen bacterial fermentation product of the naturally occurring tricarboxylic acid trans-aconitic acid. Citrate as well as tricarballylate uptake (at a concentration of 0.05 mmol l-1) was strongly stimulated by an inwardly directed initial Na+ gradient. Unequivocal evidence for a common transport site for tricarballylate and citrate was obtained from 'cis-inhibition' and 'trans-stimulation' of Na(+)-dependent citrate uptake by tricarballylate. Tricarballylate and citrate are transported across the intestinal brush-border membrane by a common, Na(+)-dependent transport mechanism[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.68mL 1.14mL 0.57mL |
28.39mL 5.68mL 2.84mL |
56.78mL 11.36mL 5.68mL |
| 参考文献 |
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