产品说明书

Foscarnet sodium

Print
Chemical Structure| 63585-09-1 同义名 : Phosphonoformic acid trisodium salt;Trisodium phosphonoformate;Phosphonoformate
CAS号 : 63585-09-1
货号 : A262254
分子式 : CNa3O5P
纯度 : 97%
分子量 : 191.951
MDL号 : MFCD00013973
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 60 mg/mL(312.58 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 DNA polymerases are essential enzymes responsible for replication and repair of DNA in all organisms[3]. Foscarnet Sodium is a viral DNA polymerase activity inhibitor,Foscarnet sodium can inhibit dNTPs thus attenuats viral RNA polymerases, reverse transcriptase, and DNA polymerases. It is used in the treatment of cytomegalovirus retinitis[4].The simultaneous infusion of foscarnet increased the renal clearance of lithium and its ratio to creatinine clearance as well as the urinary excretion of phosphate. Foscarnet also inhibited the lithium-induced phosphorylation of GSK3β[5].Foscarnet in phosphate-buffered saline decreased in a dose-dependent manner the viability of cultured human skin fibroblasts. This toxic effect was markedly decreased when foscarnet was incorporated into the polymer matrix[6].Foscarnet competes with ATP against the binding on fibroblast growth factor 2 at the heparin/ATP-binding domain. This indicates binding of foscarnet at the heparin-binding domain of FGF2. This interaction of foscarnet with fibroblast growth factor 2 reduces FGF2-induced proliferation of human umbilical vein endothelial cells and intracellular signaling via ERK1/2 kinases in this cell line[7].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.21mL

1.04mL

0.52mL

26.05mL

5.21mL

2.60mL

52.10mL

10.42mL

5.21mL
参考文献

[1]Rose K. Foscarnet reduces FGF2-induced proliferation of human umbilical vein endothelial cells and has antineoplastic activity against human anaplastic thyroid carcinoma cells. Biomed Pharmacother. 2013 Feb;67(1):53-7.

[2]Oberg B. Antiviral effects of phosphonoformate (PFA, foscarnet sodium). Pharmacol Ther. 1989;40(2):213-85.

[3] Joshua P Gill, Jun Wang,et al. DNA polymerase activity at the single-molecule level. Biochem Soc Trans.2011 Apr;39(2):595-9.

[4] Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5.

[5] Yuichi Uwai, Tatsuya Kawasaki,et al. Foscarnet, an inhibitor of the sodium-phosphate cotransporter NaPi-IIa, inhibits phosphorylation of glycogen synthase kinase-3β by lithium in the rat kidney cortex.

[6] J Piret, A Désormeaux,et al. Sodium lauryl sulfate increases the efficacy of a topical formulation of foscarnet against herpes simplex virus type 1 cutaneous lesions in mice. Antimicrob Agents Chemother. 2000 Sep;44(9):2263-70.

[7]Karsten Rose. Foscarnet reduces FGF2-induced proliferation of human umbilical vein endothelial cells and has antineoplastic activity against human anaplastic thyroid carcinoma cells. Biomed Pharmacother. 2013 Feb;67(1):53-7.