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Nigakinone

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Chemical Structure| 18110-86-6 同义名 : 苦木酮
CAS号 : 18110-86-6
货号 : A261403
分子式 : C15H10N2O3
纯度 : 98+%
分子量 : 266.26
MDL号 : N/A
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(26.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 5-Hydroxy-4-methoxycanthin-6-one, a natural product isolated and purified from the barks of Picrasma quassioides (D.Don) Benn with anti-inflammatory effect and protective effect on dextran sulfate sodium -induced rat colitis, exhibits significant cytotoxic activity against CNE2 cell line, reduces the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.56mL

7.51mL

3.76mL
参考文献

[1]Liu JF, Shao M, et al. Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis. Planta Med. 2009 Feb;75(2):142-5.

[2]Jiang MX, Zhou YJ. Canthin-6-one alkaloids from Picrasma quassioides and their cytotoxic activity. J Asian Nat Prod Res. 2008 Nov-Dec;10(11-12):1009-12.