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Dimethyl fumarate

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Chemical Structure| 624-49-7 同义名 : NSC 25942;trans-Butenedioic Acid dimethyl ester;DMF;NSC 167432
CAS号 : 624-49-7
货号 : A258585
分子式 : C6H8O4
纯度 : 99%
分子量 : 144.125
MDL号 : MFCD00064438
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(277.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dimethyl fumarate (DMF) functions as an orally active, brain-penetrant activator of Nrf2, leading to the upregulation of antioxidant gene expression. It triggers necroptosis in colon cancer cells via a mechanism involving GSH depletion, ROS increase, and MAPKs activation, and also induces cell autophagy, making it relevant for multiple sclerosis research[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.94mL

1.39mL

0.69mL

34.69mL

6.94mL

3.47mL

69.38mL

13.88mL

6.94mL
参考文献

[1]Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug;172(15):3929-43.

[2]Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26.

[3]Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12;286:131-40