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CAY10444

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Chemical Structure| 298186-80-8 同义名 : BML-241
CAS号 : 298186-80-8
货号 : A256956
分子式 : C15H29NO2S
纯度 : 95%
分子量 : 287.461
MDL号 : MFCD08062140
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(139.15 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CAY10444 , also known as BML-241, is an S1P3 antagonist. CAY10444 inhibits the S1P-induced increase in Ca2+ by 37% in HeLa cells expressing the S1P3 receptor[1].BML-241 inhibited the increase in intracellular Ca2+ concentration induced by stimulation via P2 receptors or α1A adrenergic receptors and α1A adrenergic receptor-mediated constriction of rat mesenteric arteries without affecting the S1P3-mediated decrease in forskolin-induced cAMP accumulation[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.48mL

0.70mL

0.35mL

17.39mL

3.48mL

1.74mL

34.79mL

6.96mL

3.48mL
参考文献

[1]Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.