Oseltamivir phosphate

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Chemical Structure| 204255-11-8 同义名 : GS 4104 phosphate;Oseltamivir (phosphate);Tamiflu®;Ro 64-0796/002;GS-4104;Tamiflu
CAS号 : 204255-11-8
货号 : A255018
分子式 : C16H31N2O8P
纯度 : 98%
分子量 : 410.4
MDL号 : MFCD08059548
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(255.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(243.66 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Oseltamivir is an antiviral neuraminidase inhibitor used for the treatment and prevention of infection with influenza viruses A (including pandemic H1N1) and B (flu). Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which prevents budding from the host cell, viral replication, and infectivity. The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir prevents new viral particles from being released[1].
细胞研究
细胞系 浓度 检测类型 检测时间 活动说明 数据源
MDCK cells Function assay 36 h Antiinfluenza activity against influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 36 hrs, IC50=1.1 μM 22341943
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02927431 Virus Diseases Phase 2 Terminated(The study was stopp... 展开 >>ed early due to lack of enrollment.) 收起 << - -
NCT02927431 - Terminated(The study was stopp... 展开 >>ed early due to lack of enrollment.) 收起 << - -
NCT01156701 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.44mL

0.49mL

0.24mL

12.18mL

2.44mL

1.22mL

24.37mL

4.87mL

2.44mL
参考文献

[1]Leneva IA, Roberts N, et al. The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral Res. 2000 Nov;48(2):101-15.

[2]Li W, Escarpe PA, et al. Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother. 1998 Mar;42(3):647-53.