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Tie2 kinase inhibitor 1

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Chemical Structure| 948557-43-5 同义名 : Tunica Interna Endothelial Cell Kinase 2 Inhibitor;Tie2 Kinase Inhibitor;Compound 5;Tie2 kinase inhibitor 5;Tie2 inhibitor 5;Tie2-IN-5
CAS号 : 948557-43-5
货号 : A253059
分子式 : C26H21N3O2S
纯度 : 99%+
分子量 : 439.529
MDL号 : MFCD18384977
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(36.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Tie-2

    Tie-2, IC50:0.25 μM
描述 Tie2 kinase inhibitor 1 is a strong and selective inhibitor of Tie2 kinase, exhibiting an IC50 value of 250 nM. It has shown an IC50 of 50 μM against p38 and demonstrates moderate to high efficacy in cellular assays, with a cellular IC50 of 232 nM[1]. It exhibits anti-cancer properties[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.28mL

0.46mL

0.23mL

11.38mL

2.28mL

1.14mL

22.75mL

4.55mL

2.28mL
参考文献

[1]Semones M, et al. Pyridinylimidazole inhibitors of Tie2 kinase. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4756-60. Epub 2007 Jun 27.

[2]Hasenstein JR, et al. Efficacy of Tie2 receptor antagonism in angiosarcoma. Neoplasia. 2012 Feb;14(2):131-40.