产品说明书

JBSNF-000088

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Chemical Structure| 7150-23-4 同义名 : 6-Methoxynicotinamide;NSC 70628
CAS号 : 7150-23-4
货号 : A251914
分子式 : C7H8N2O2
纯度 : 98%
分子量 : 152.151
MDL号 : -
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(690.11 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 1 mg/mL(6.57 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 JBSNF-000088, an analogue of nicotinamide (NA), is a potent, orally active NNMT inhibitor with IC50 values of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT, and mouse NNMT, respectively. JBSNF-000088 inhibits NNMT activity, reduces MNA levels, and promotes insulin secretion, glucose regulation and weight loss in animal models of metabolic diseases. The IC50 values of JBSNF-000088 on U2OS or differentiated 3T3L1 cells were 1.6 µM and 6.3 µM, respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

6.57mL

1.31mL

0.66mL

32.86mL

6.57mL

3.29mL

65.72mL

13.14mL

6.57mL
参考文献

[1]Kannt A, et al. A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders. Sci Rep. 2018 Feb 26;8(1):3660.