产品说明书

2-PMPA

Print
Chemical Structure| 173039-10-6 同义名 : 2-(Phosphonomethyl)pentanedioic acid
CAS号 : 173039-10-6
货号 : A250784
分子式 : C6H11O7P
纯度 : 95%
分子量 : 226.121
MDL号 : MFCD00940167
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 28 mg/mL(123.83 mM)
动物实验配方：
生物活性
描述 2-PMPA stands out as a highly effective and specific GCPII inhibitor, an enzyme responsible for breaking down the widely present neuropeptide NAAG into NAA and glutamate, with IC50 value of 300 pM. It has shown considerable success in a variety of animal models for neurological disorders. Due to its high polarity and several negative charges, 2-PMPA presents substantial analytical challenges in biological matrices[1]. 2-PMPA mitigates the reduction in cell viability and the elevation of LDH levels caused by ketamine in mixed cell cultures, while these effects are not observed in neuronal cultures alone[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.42mL

0.88mL

0.44mL

22.11mL

4.42mL

2.21mL

44.22mL

8.84mL

4.42mL
参考文献

[1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014 Jan;88:162-9.

[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.

[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26(1):1-15.

[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51(7-8):1163-71.