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Cyclo(-RGDfK)

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Chemical Structure| 161552-03-0 同义名 : Cyclo(Arg-Gly-Asp-D-Phe-Lys)
CAS号 : 161552-03-0
货号 : A249950
分子式 : C27H41N9O7
纯度 : 98%
分子量 : 603.671
MDL号 : MFCD00937400
存储条件:

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 85 mg/mL(140.81 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(82.83 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.66mL

0.33mL

0.17mL

8.28mL

1.66mL

0.83mL

16.57mL

3.31mL

1.66mL

参考文献

[1]Lopez-Rodriguez V, Gaspar-Carcamo RE, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.

[2]Simecek J, Notni J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.