产品说明书
Methyl gallate
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同义名 : | 3,4,5-三羟基苯甲酸甲酯 ;Gallincin;NSC 363001;Gallicin;Gallic acid methyl ester |
| CAS号 : | 99-24-1 | |
| 货号 : | A249559 | |
| 分子式 : | C8H8O5 | |
| 纯度 : | 98% | |
| 分子量 : | 184.146 | |
| MDL号 : | MFCD00002194 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(570.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Methyl gallate is a plant phenolic with antioxidant, anticancer, and anti-inflammatory activities. The growth of A. viscosus is inhibited completely by a low dose of Methyl gallate (MIC=1 mg/mL). S. mutans and . sobrinus show intermediate sensitivity to Methyl gallate (MIC=2-4 mg/mL), whereas the growth of Lactobacillus spp. is inhibited completely at a relatively high concentration (MIC=8 mg/mL)[3]. MG (Methyl gallate) effectively inhibited the growth of both promastigote (IC50 5.71 μM) and amastigote-like forms (EC50 5.39 μM), with much higher selectivity indexes than the reference drugs, being more benign towards J774A.1 macrophages than meglumine antimoniate and amphotericin B, at 1631- and 70.92-fold respectively, with respect to the promastigote form. Additionally, MG proved to be even more active against intracellular amastigotes of the parasite (EC50 4.24 μM). In addition, MG induced increased phagocytic capability, and lysosomal volume in macrophages; structural parameters of microbicidal activity[4]. Methyl gallate, in a concentration of 100 mM, could alleviate lipid peroxidation of the cells exposed to a short-term H2O2 treatment. In addition, Methyl gallate-treated cells could prevent intracellular glutathione (GSH) from being depleted following an exposure of H2O2 (8.0 mM) for a 3 h period[5]. Methyl gallate inhibits Treg cell-suppressive effects on effector CD4+ T cells and Treg migration toward tumor environment. Furthermore, forkhead box P3 (Foxp3) expression is also significantly decreased by methyl gallate[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00917735 | Breast Cancer | Phase 2 | Completed | - | United States, Minnesota ... 展开 >> Fairview Southdale Breast Center Edina, Minnesota, United States, 55435 Fairview Maple Grove Breast Center Maple Grove, Minnesota, United States, 55369 University of Minnesota Medical Center (UMMC) Breast Clinic Minneapolis, Minnesota, United States, 55455 Park Nicollet Institute St. Louis Park, Minnesota, United States, 55426 Food Science and Nutrition, University of Minnesota St. Paul, Minnesota, United States, 55108 收起 << |
| NCT01699711 | Down Syndrome (DS) | Phase 2 | Completed | - | Spain ... 展开 >> IMIM (Institut Hospital del Mar d'Investigacions Mèdiques) Barcelona, Spain, 08003 收起 << |
| NCT00917735 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.43mL 1.09mL 0.54mL |
27.15mL 5.43mL 2.72mL |
54.30mL 10.86mL 5.43mL |
| 参考文献 |
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