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JCP174

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Chemical Structure| 126062-19-9 同义名 : 7-amino-4-chloro-3-Propoxyisocoumarin
CAS号 : 126062-19-9
货号 : A249163
分子式 : C12H12ClNO3
纯度 : 98%+
分子量 : 253.682
MDL号 : MFCD22378306
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 JCP174 is an inhibitor of TgPPT1, a depalmitoylase in parasite T. gondii[1].JCP174 is also an inhibitor of porcine pancreatic elastase and human leukocyte elastase[2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.94mL

0.79mL

0.39mL

19.71mL

3.94mL

1.97mL

39.42mL

7.88mL

3.94mL
参考文献

[1]Child MA, et al. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nat Chem Biol. 2013 Oct;9(10):651-6.

[2]Powers JC, et al. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin. Biochemistry. 1990 Mar 27;29(12):3108-18.

[3]Kerrigan JE, et al. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency. J Med Chem. 1995 Feb 3;38(3):544-52.