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Pneumocandin B0

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Chemical Structure| 135575-42-7 同义名 : L-688786;Hydroxy Echinocandin
CAS号 : 135575-42-7
货号 : A248329
分子式 : C50H80N8O17
纯度 : 98%
分子量 : 1065.214
MDL号 : MFCD28168025
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(98.57 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cancidas is the first of a new class of antifungals, the echinocandins. It has been approved by the FDA for treatment of invasive aspergillosis in patients who fail to respond to or are unable to tolerate other antifungal drugs[3]. Pneumocandin B0 is an intermediate in the production of the antifungal drug, Cancidas[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.94mL

0.19mL

0.09mL

4.69mL

0.94mL

0.47mL

9.39mL

1.88mL

0.94mL
参考文献

[1]Welch CJ, DaSilva JO, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101(1-2):204-13.

[2]Leonard WR Jr, et al. Determination of the relative and absolute configuration of the dimethylmyristoyl side chain of pneumocandin B0 by asymmetric synthesis. Org Lett. 2002 Nov 28;4(24):4201-4.

[3]Caspofungin (Cancidas) for Aspergillosis

[4]Preparation and Evaluation of Novel Stationary Phases for Improved Chromatographic Purification of Pneumocandin B0