产品说明书
3MB-PP1
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同义名 : | - |
| CAS号 : | 956025-83-5 | |
| 货号 : | A247643 | |
| 分子式 : | C17H21N5 | |
| 纯度 : | 95% | |
| 分子量 : | 295.382 | |
| MDL号 : | MFCD11655904 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(355.47 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 3MB-PP1 is a bulky purine analog and a PLK1 inhibitor. In cells expressing an analogue-sensitive Plk1 allele, 3MB-PP1 blocks mitotic progression and cytokinesis by targeting PLK1. 3MB-PP1 specifically inhibits analogue-sensitive Cdk8 activity. 3MB-PP1 inhibits Leu93-ZIPK with an IC50 value of 2 μM. 3MB-PP1 can be used to study Candida albicans mycelium formation and cell division[1][2][3].3-MB-PP1 at 5μM stimulates hyphal growth in a strain bearing analog-sensitive alleles of CDK8, post 3-hour treatment at 30℃[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.39mL 0.68mL 0.34mL |
16.93mL 3.39mL 1.69mL |
33.85mL 6.77mL 3.39mL |
| 参考文献 |
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