Indirubin

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Chemical Structure| 479-41-4 同义名 : Couroupitine B;Indigo red;C.I. 73200, Couroupitine B, Indigo red, Indigopurpurin, NSC 105327;C.I. 73200;NSC 105327;Indigopurpurin
CAS号 : 479-41-4
货号 : A244764
分子式 : C16H10N2O2
纯度 : 98%
分子量 : 262.26
MDL号 : MFCD00221745
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 4 mg/mL(15.25 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • GSK-3β

    GSK-3β, IC50:0.6 μM
描述 Indirubin (Couroupitine B), a bis-indole alkaloid, is recognized for its remarkable anticancer efficacy, particularly against chronic myelocytic leukemia[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.81mL

0.76mL

0.38mL

19.07mL

3.81mL

1.91mL

38.13mL

7.63mL

3.81mL
参考文献

[1]Kim MH, et al. Indirubin, a purple 3,2- bisindole, inhibited allergic contact dermatitis via regulating T helper (Th)-mediated immune system in DNCB-induced model. J Ethnopharmacol. 2013 Jan 9;145(1):214-9.

[2]Hsieh WL, et al. Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes. J Dermatol Sci. 2012 Aug;67(2):140-6.

[3]Zhang X, et al. Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2-mediated JAK/STAT3 signaling in endothelial cell. Int J Cancer. 2011 Nov 15;129(10):2502-11.