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Pimavanserin hemitartrate

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Chemical Structure| 706782-28-7 同义名 : ACP-103;Pimavanserin tartrate;ACP-103 hemitartrate
CAS号 : 706782-28-7
货号 : A244461
分子式 : C54H74F2N6O10
纯度 : 99%
分子量 : 1005.196
MDL号 : MFCD09970919
存储条件：

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(79.59 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(49.74 mM)，配合低频超声助溶
动物实验配方：

PO 0.5% CMC-Na 36 mg/mL suspension

生物活性
靶点

  • 5-HT2

    5-HT2A, pIC50:8.7
描述 Pimavanserin is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson's disease.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.99mL

0.20mL

0.10mL

4.97mL

0.99mL

0.50mL

9.95mL

1.99mL

0.99mL
参考文献

[1]Vanover KE, Betz AJ, et al. A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model. Pharmacol Biochem Behav. 2008 Oct;90(4):540-4.

[2]Vanover KE, Weiner DM, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.