Hydroxyfasudil

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Chemical Structure| 105628-72-6 同义名 : HA-1100
CAS号 : 105628-72-6
货号 : A244270
分子式 : C14H17N3O3S
纯度 : 99%+
分子量 : 307.368
MDL号 : MFCD01752417
存储条件：

Pure form Keep in dark place,Inert atmosphere,Room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(97.6 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Hydroxyfasudil, a ROCK inhibitor, shows IC50 values of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively. It less potently inhibits PKA with an IC50 of 37 μM. Hydroxyfasudil enhances eNOS mRNA levels (EC50 of 0.8 ± 0.3 μM), and between 0-100 μM, it increases eNOS activity and stimulates NO production in human aortic endothelial cells (HAEC). At 10 μM, it prolongs the half-life of eNOS mRNA from 13 to 16 hours without affecting eNOS promoter activity [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.33mL

16.27mL

3.25mL

1.63mL

32.53mL

6.51mL

3.25mL
参考文献

[1]Rikitake Y, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke. 2005 Oct;36(10):2251-7. Epub 2005 Sep 1.

[2]Masago T, et al. Effect of the rho-kinase inhibitor hydroxyfasudil on bladder overactivity: an experimental rat model. Int J Urol. 2009 Oct;16(10):842-7.

[3]Saito M, et al. Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat. Pharmacol Res. 2012 Oct;66(4):325-31.