产品说明书

Euxanthone

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Chemical Structure| 529-61-3 同义名 : -
CAS号 : 529-61-3
货号 : A244139
分子式 : C13H8O4
纯度 : 98%
分子量 : 228.2
MDL号 : MFCD00914848
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Euxanthone, a natural product isolated and purified from the roots of Polygala tenuifolia Willd., induces neurite outgrowth which actively regulated by transcription factor E2F-5 via PKC pathway. Euxanthone also induces its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C, has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, and induces differentiation of the neuroblastoma BU-1 cells that may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.82mL

8.76mL

4.38mL

参考文献

[1]Camara DV, Lemos VS, et al. Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries. Phytomedicine. 2010 Jul;17(8-9):690-2.

[2]Fang LH, Mu YM, et al. Vasorelaxant effect of euxanthone in the rat thoracic aorta. Vascul Pharmacol. 2006 Aug;45(2):96-101.